ATHENA Network

Date

Thu May 12th 10:00am to 11:00am PDT

Presenter

Olivier Harismendy

Abstract

The Athena Breast Health Network is a research and care collaboration across the five UC Medical Centers and Sanford Health. In response to the controversy on breast cancer screening guidelines, the network started the WISDOM (Women Informed to Screen Depending On Measures of risk) study to prospectively evaluate a risk-based screening strategy. This strategy incorporates the latest risk assessment model along with co-morbidities, breast density and genetic risk factors. In particular, the DNA of more than 100,000 women will be sequenced at 9 breast cancer risk genes and 76 susceptibiity SNPs. I will describe the study, its goals, rational and participating sites, as well the infrastructure deployed to share the genetic results within the ATHENA Network using the iDASH HIPAA compliant cloud and the Application Programmable Interface from the Global Alliance for Genomic and Health. Progress and Limitations will be discussed. 

Bios

Dr. Harismendy graduated with an M.S. in Process Engineering from ENSTA-ParisTech (France) and a joint M.S. in Microbiology from the Pasteur Institute and Paris 7 University. He obtained his Ph.D. in Microbiology from the same university, studying RNA polymerase III transcriptional regulation in yeast using ChIP-chip at Dr Sentenac’s laboratory (CEA-Saclay, France). He then joined Dr. Edelman’s Department of Neurobiology at The Scripps Research Institute (La Jolla, CA), where he developed ChIP-Seq approaches to study Neuron Restrictive Silencing Factor DNA binding in mouse developing brains.

Under the mentorship of Dr. Kelly Frazer, Dr. Harismendy went on to develop applications of high-throughput sequencing for translational research: evaluating methods for targeted sequencing, exploring the role of regulatory variants in common diseases, and detecting and studying the role of somatic mutations in cancer. He joined the UC San Diego Moores Cancer Center in 2009 where he is currently leading the Oncogenomics laboratory. His current research focuses on the development of assays and computational approaches to study tumor heterogeneity predict drug response and understand the contribution of gene regulatory elements in cancer etiology and progression. Strong of his experience in the molecular analysis of clinical samples and the interpretation of the data for cancer care, Dr. Harismendy participates in the molecular tumor board and the protocol monitoring and review committee to review and advise on the design and execution of molecularly guided clinical trials.

 

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